Synthesis and cytotoxic activity of pyridazino[1',6':1,2]pyrido[3,4-b]indol-5-inium derivatives as anti-cancer agents

  • Bioorg Med Chem Lett. 2002 Sep 16;12(18):2611-4. doi: 10.1016/s0960-894x(02)00472-9.
Alberto Fontana  1 ,  Enrique J Benito ,  M Justina Martín ,  Nuria Sánchez ,  Ramón Alajarín ,  J José Vaquero ,  Julio Alvarez-Builla ,  Stéphanie Lambel-Giraudet ,  Stéphane Leonce ,  Alain Pierré ,  Daniel Caignard
Affiliations
  • 1. Departamento de Qui;mica Orgánica, Universidad de Alcalá, 28871-Alcalá de Henares, Madrid, Spain.
PMID: 12182872 DOI: 10.1016/s0960-894x(02)00472-9
Abstract

Several new pyridazino[1',6':1,2]pyrido[3,4-b]indol-5-inium derivatives were synthesised from beta-carboline derivatives and their cytotoxic activity and effect on the cell cycle were evaluated against L1210 Cancer cells.