Antimalarial activity of yingzhaosu A analogues

  • J Med Chem. 2002 Oct 10;45(21):4732-6. doi: 10.1021/jm020208q.
Hye-Sook Kim  1 ,  Khurshida Begum ,  Naoki Ogura ,  Yusuke Wataya ,  Takahiro Tokuyasu ,  Araki Masuyama ,  Masatomo Nojima ,  Kevin J McCullough
Affiliations
  • 1. Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700-8530, Japan.
PMID: 12361400 DOI: 10.1021/jm020208q
Abstract

Iodonium ion mediated cyclization of unsaturated hydroperoxides 1 afforded the expected yingzhaosu A analogues 2. In some cases, however, the corresponding cyclic ethers 5 were formed competitively with the cyclic peroxides 2, the ratios of these two products being a marked function of the structure of the starting Materials. Some of the cyclic peroxides 2 showed significant antimalarial activities in vitro and in vivo.