New bioactive rosigenin analogues and aromatic polyketide metabolites from the freshwater aquatic fungus Massarina tunicata

  • J Nat Prod. 2003 Jan;66(1):73-9. doi: 10.1021/np020342d.
Hyuncheol Oh  1 ,  Dale C Swenson ,  James B Gloer ,  Carol A Shearer
Affiliations
  • 1. Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
PMID: 12542349 DOI: 10.1021/np020342d
Abstract

Four new rosigenin analogues (massarigenins A-D; 1-4) and two new aromatic polyketide-derived secondary metabolites (massarinins A and B; 6, 7) and have been isolated from the freshwater aquatic fungus Massarina tunicata. The structures of these compounds were determined primarily by analysis of NMR data, and that of compound 1 was verified by X-ray crystallography. The known compound 4-(2-hydroxybutynoxy)benzoic acid (11) was also obtained, and its absolute stereochemistry was assigned. Several of these metabolites showed Antibiotic activity against Gram-positive bacteria.

Products