Ciwujianosides D1 and C1: powerful inhibitors of histamine release induced by anti-immunoglobulin E from rat peritoneal mast cells

  • J Pharm Sci. 1992 Jul;81(7):661-2. doi: 10.1002/jps.2600810714.
A Umeyama  1 ,  N Shoji ,  M Takei ,  K Endo ,  S Arihara
Affiliations
  • 1. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
PMID: 1383492 DOI: 10.1002/jps.2600810714
Abstract

In rat peritoneal mast cells induced by anti-immunoglobulin E, ciwujianosides D1 (1) and C1 (2) from Acanthopanax senticosus (ciwujia) strongly inhibited histamine release in a concentration-dependent manner. The inhibitory effect of 1 was approximately 6800 times stronger than that of disodium cromoglycate.

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