Glisoprenins, new inhibitors of acyl-CoA: cholesterol acyltransferase produced by Gliocladium sp. FO-1513. II. Structure elucidation of glisoprenins A and B

  • J Antibiot (Tokyo). 1992 Oct;45(10):1669-76. doi: 10.7164/antibiotics.45.1669.
H Nishida  1 ,  X H Huang ,  H Tomoda ,  S Omura
Affiliations
  • 1. Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
PMID: 1473995 DOI: 10.7164/antibiotics.45.1669
Abstract

The structure of glisoprenins A and B, novel acyl-CoA: cholesterol Acyltransferase (ACAT) inhibitors, was determined by spectroscopic analyses, mainly 1H and 13C NMR and MS. Glisoprenin A was deduced to be a tetrahydroxynonaprenol and glisoprenin B to be an oxidative modification of glisoprenin A.

Products