Bicyclic anti-VZV nucleosides: thieno analogues bearing an alkylphenyl side chain have reduced antiviral activity

  • Bioorg Med Chem Lett. 2004 May 17;14(10):2397-9. doi: 10.1016/j.bmcl.2004.03.029.
Annette Angell  1 ,  Christopher McGuigan ,  Luis Garcia Sevillano ,  Robert Snoeck ,  Graciela Andrei ,  Erik De Clercq ,  Jan Balzarini
Affiliations
  • 1. Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK.
PMID: 15109620 DOI: 10.1016/j.bmcl.2004.03.029
Abstract

Thieno analogues of the potent and selective furo-pyrimidine anti-VZV nucleoside family bearing a p-alkylphenyl side chain have been synthesised and tested for their Antiviral activity against Varicella-Zoster virus (VZV). While the alkyl chain analogues were shown to retain full Antiviral activity against VZV, these new analogues did not when compared to their furo parent nucleosides.