Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas

  • Bioorg Med Chem Lett. 2005 Jan 3;15(1):25-8. doi: 10.1016/j.bmcl.2004.10.044.
Jeremy N Burrows  1 ,  John G Cumming ,  Shaun M Fillery ,  Gordon A Hamlin ,  Julian A Hudson ,  Ruth J Jackson ,  Sharon McLaughlin ,  John S Shaw
Affiliations
  • 1. Respiratory and Inflammation Research Area, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK.
PMID: 15582404 DOI: 10.1016/j.bmcl.2004.10.044
Abstract

Investigation of weak screening hits led to the identification of N-alkyl-N-[1-(3,3-diphenylpropyl)piperidin-4-yl]-2-phenylacetamides and N-alkyl-N-[1-(3,3-diphenylpropyl)piperidin-4-yl]-N'-benzylureas as potent, selective ligands for the human CCR5 Chemokine Receptor.

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