Larvicidal, antimycobacterial and antifungal compounds from the bark of the Peruvian plant Swartzia polyphylla DC

  • Chem Pharm Bull (Tokyo). 2006 Feb;54(2):278-9. doi: 10.1248/cpb.54.278.
Rosario Rojas  1 ,  Betty Bustamante ,  Palmira Ventosilla ,  Irma Fernádez ,  Luz Caviedes ,  Robert Henry Gilman ,  Olga Lock ,  Gerald Bruce Hammond
Affiliations
  • 1. Departamento de Ciencias Farmacéuticas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.
PMID: 16462085 DOI: 10.1248/cpb.54.278
Abstract

The 95% ethanol extract of the bark of Swartzia polyphylla DC (Fabaceae) possesses important larvicidal, antimycobacterial and Antifungal activity in vitro. Bioassay-guided studies performed on the crude ethanol extract afforded T-cadinol as the larvicidal and anti-Mycobacterium tuberculosis principle, while the Antifungal activity of the extract is due to the presence of the Flavonoids biochanin A and dihydrobiochanin A.

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