A pyrimidine-pyrazolone nucleoside chimera with potent in vitro anti-orthopoxvirus activity

  • Bioorg Med Chem Lett. 2006 Jun 15;16(12):3224-8. doi: 10.1016/j.bmcl.2006.03.043.
Xuesen Fan  1 ,  Xinying Zhang ,  Longhu Zhou ,  Kathy A Keith ,  Earl R Kern ,  Paul F Torrence
Affiliations
  • 1. Department of Chemistry and Biochemistry, Northern Arizona University, Flagstaff, AZ 86011, USA.
PMID: 16603351 DOI: 10.1016/j.bmcl.2006.03.043
Abstract

Synthetic hybridization of two privileged drug scaffolds, pyrazolone on the one hand and pyrimidine nucleoside on the Other, resulted in the generation of two novel 5-substituted pyrimidine nucleosides with potent in vitro Antiviral activity against two representative orthopoxviruses, vaccinia virus and cowpox virus.