PTP1B inhibitors from Saussrurea lappa

  • J Asian Nat Prod Res. 2006 Apr-May;8(3):281-6. doi: 10.1080/10286020412331286434.
S Li  1 ,  T-Y An ,  J Li ,  Q Shen ,  F-C Lou ,  L-H Hu
Affiliations
  • 1. Department of Phytochemistry, China Pharmaceutical University, Nanjing 210038, China.
PMID: 16864436 DOI: 10.1080/10286020412331286434
Abstract

A new lignan glycoside, named 1,5-dihydroxypinoresinol-4'-O-beta-d-glucopyranoside (1), has been isolated from the EtOH extract of the roots of Saussurea lappa, together with twenty known compounds: (+)-1-hydroxypinoresinol-1-O-beta-D-glucopyranoside (2), fraxiresinol-4'-O-beta-D-glucopyranoside (3), (-)-olivil-4''-O-beta-D-glucopyranoside (4), 4-allyl-2,6-dimethoxybenzene-1-O-beta-D-glucopyranoside, syringin, costunolide-15-O-beta-D-glucopyranoside, chlorogenic acid, aloe-emodin-8-O-beta-D-glucopyranoside (5), rhein-8-O-beta-D-glucopyranoside (6), chrysophanol (7), emodin, dehydrocostus lactone, costunolide, beta-costic acid, reynosin, arbusculin A, alpha-cyclocostunolide, beta-cyclocostunolide, santamarine and magnolialide. Three Anthraquinones (5-7) showed moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro.

Products