Estrogenic activity of furanocoumarins isolated from Angelica dahurica

  • Arch Pharm Res. 2006 Sep;29(9):741-5. doi: 10.1007/BF02974073.
Xiang Lan Piao  1 ,  Hye Hyun Yoo ,  Hyun Young Kim ,  Tak Lim Kang ,  Gwi Seo Hwang ,  Jeong Hill Park
Affiliations
  • 1. School of Pharmaceutical Sciences, Peking University, Beijing 100083, China.
PMID: 17024846 DOI: 10.1007/BF02974073
Abstract

In our efforts to discover novel phytoestrogens to treat menopausal symptoms, eleven furanocoumarins were isolated from Angelica dahurica and tested for their estrogenic activity on the Ishikawa cell line. Among the compounds tested, 9-hydroxy-4-methoxypsoralen and alloisoimperatorin showed strong abilities to induce Alkaline Phosphatase (AP) with EC50 values of 1.1 and 0.8 microg/mL, respectively, whereas the Other nine furanocoumarins were weakly or only slightly active.

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