Cytotoxic hypothemycin analogues from Hypomyces subiculosus
- J Nat Prod. 2006 Oct;69(10):1456-9. doi: 10.1021/np060258o.
Affiliations
- 1. Kosan Biosciences, Inc., Hayward, California 94545, USA. [email protected]
PMID: 17067161
DOI: 10.1021/np060258o
Abstract
Three new hypothemycin analogues were isolated from the Fungal strains Hypomyces subiculosus DSM 11931 and DSM 11932. The structures of these compounds were elucidated by spectroscopic methods, chemical conversion, and X-ray crystallographic analysis. One of the analogues, 4-O-demethylhypothemycin, exhibited potent and selective cytotoxic activity against cell lines with a BRAF mutation.