Novel poly(ADP-ribose) polymerase-1 inhibitors

  • Bioorg Med Chem Lett. 2007 Jan 15;17(2):542-5. doi: 10.1016/j.bmcl.2006.10.010.
Derek Dunn  1 ,  Jean Husten ,  Mark A Ator ,  Sankar Chatterjee
Affiliations
  • 1. Cephalon Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA.
PMID: 17074482 DOI: 10.1016/j.bmcl.2006.10.010
Abstract

Synthesis and activity of a series of 4-thiazol-yl substituted analogs of novel pyrrolocarbazole 1 as poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors have been disclosed.