A pair of novel cytotoxic polyprenylated xanthone epimers from gamboges

  • Chem Biodivers. 2006 Jan;3(1):101-5. doi: 10.1002/cbdv.200690000.
Quan-Bin Han  1 ,  Ling Yang ,  Yu-Lin Wang ,  Chun-Feng Qiao ,  Jing-Zheng Song ,  Han-Dong Sun ,  Hong-Xi Xu
Affiliations
  • 1. Laboratory of Chinese Medicine, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, PR China.
PMID: 17193222 DOI: 10.1002/cbdv.200690000
Abstract

Two new polyprenylated xanthone epimers were isolated from gamboges of Garcinia hanburyi, and identified by detailed spectroscopic analysis as 30-hydroxygambogic acid (2a) and its (2S)-epimer 30-hydroxyepigambogic acid (2b). Both compounds exhibited significant cytotoxicities against the human leukemia K562/S and the corresponding doxorubicin-resistant K562/R cell lines (Table 2).

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