Antiviral flavonoid-type C-glycosides from the flowers of Trollius chinensis

  • Chem Biodivers. 2006 Mar;3(3):343-8. doi: 10.1002/cbdv.200690037.
Shao-Qing Cai  1 ,  Rufeng Wang ,  Xiuwei Yang ,  Mingying Shang ,  Chaomei Ma ,  Yukihiro Shoyama
Affiliations
  • 1. The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, PR China. [email protected]
PMID: 17193271 DOI: 10.1002/cbdv.200690037
Abstract

Two new flavonoid-type C-glycosides, trollisin I (= (1S)-1,5-anhydro-1-[2-(3,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-4-oxo-4H-[1]benzopyran-8-yl]-2-O-(2-methylbutanoyl)-D-glucitol; 1) and its 2-O-benzoyl congener trollisin II (2), were isolated from Trollius chinensis Bunge, together with the two known compounds 2''-O-(2'''-methylbutanoyl)isoswertisin (3) and vitexin galactoside (4). All compounds were identified by HR-ESI-MS and in-depth NMR-spectroscopic analyses. In Antiviral assays, compound 3 was found to be moderately active towards Influenza Virus A.

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