Synthesis, DNA binding, and cytotoxicity studies of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates

  • Bioorg Med Chem. 2007 Nov 15;15(22):6868-75. doi: 10.1016/j.bmc.2007.08.026.
Ahmed Kamal  1 ,  R Ramu ,  Venkatesh Tekumalla ,  G B Ramesh Khanna ,  Madan S Barkume ,  Aarti S Juvekar ,  Surekha M Zingde
Affiliations
  • 1. Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India. [email protected]
PMID: 17822905 DOI: 10.1016/j.bmc.2007.08.026
Abstract

A series of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates have been prepared and evaluated for their DNA binding ability as well as Anticancer activity. Some of these molecules have shown significant Anticancer activity in a number of Cancer cell lines.