Novel propeptin analog, propeptin-2, missing two amino acid residues from the propeptin C-terminus loses antibiotic potency

  • J Antibiot (Tokyo). 2007 Aug;60(8):519-23. doi: 10.1038/ja.2007.66.
Ken-ichi Kimura  1 ,  Mai Yamazaki ,  Noriko Sasaki ,  Tetsuro Yamashita ,  Shigenori Negishi ,  Takemichi Nakamura ,  Hiroyuki Koshino
Affiliations
  • 1. Faculty of Agriculture, Iwate University, Morioka 020-8550, Japan. [email protected]
PMID: 17827663 DOI: 10.1038/ja.2007.66
Abstract

A novel inhibitor of prolyl endopeptidase, the propeptin analog propeptin-2 (C105H130N24O(24)), missing two amino acid residues from the propeptin C-terminus was isolated from the fermentation broth of propeptin-producing Microbispora sp. SNA-115 grown using a large inoculum. It shows the same enzyme inhibition activity as propeptin against prolyl endopeptidase (Ki=1.5 microM), but its antimicrobial activity against Mycobacterium phlei is more than 100-fold lower.

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