The expedient synthesis of 1,5-benzothiazepines as a family of cytotoxic drugs

  • Bioorg Med Chem Lett. 2008 Jan 1;18(1):114-9. doi: 10.1016/j.bmcl.2007.11.002.
Kapil Arya  1 ,  Anshu Dandia
Affiliations
  • 1. Indian Oil Corporation Limited, R&D Centre, Faridabad, Haryana 121007, India. [email protected]
PMID: 18023182 DOI: 10.1016/j.bmcl.2007.11.002
Abstract

The expedient synthesis of 1,5-benzothiazepines using LaY zeolite under stirring condition is reported and synthesized compound screened for cytotoxic activity. The reaction produces the product in relatively low yields and requires a long time when they were performed in various Solvents under conventional and microwave irradiation. Thus, the procedure provides a simple and green synthetic methodology under environmentally friendly conditions.