Structure and function of plant acyl-CoA oxidases

  • Plant Physiol Biochem. 2008 Mar;46(3):292-301. doi: 10.1016/j.plaphy.2007.12.014.
Susan Arent  1 ,  Valerie E Pye ,  Anette Henriksen
Affiliations
  • 1. Biostructure Group, Carlsberg Laboratory, Gamle Carlsberg Vej 10, DK-2500 Valby, Denmark.
PMID: 18272379 DOI: 10.1016/j.plaphy.2007.12.014
Abstract

Acyl-CoA oxidases (in peroxisomes) and acyl-CoA dehydrogenases (in mitochondria) catalyse the first step in fatty acid beta-oxidation, the pathway responsible for lipid catabolism and plant hormone biosynthesis. The interplay and differences between peroxisomal and mitochondrial beta-oxidation processes are highlighted by the variation in the Enzymes involved. Structure and sequence comparisons are made with a focus on the enzyme's mechanistic means to control electron transfer paths, reactivity towards molecular oxygen, and spatial and architectural requirements for substrate discrimination.

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