Potent inhibitors of the hedgehog signaling pathway

  • J Med Chem. 2008 Mar 13;51(5):1108-10. doi: 10.1021/jm070694n.
Shirley A Brunton  1 ,  John H A Stibbard ,  Lee L Rubin ,  Lawrence I Kruse ,  Oivin M Guicherit ,  Edward A Boyd ,  Steven Price
Affiliations
PMID: 18275133 DOI: 10.1021/jm070694n
Abstract

A small family of phenyl quinazolinone ureas is reported as potent modulators of Hedgehog protein function. Preliminary SAR studies of the urea substituent led to a nanomolar Hedgehog antagonist.

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