Identification of phoslactomycin E as a metabolite inducing hyphal morphological abnormalities in Aspergillus fumigatus IFO 5840

  • J Antibiot (Tokyo). 2007 Dec;60(12):762-5. doi: 10.1038/ja.2007.101.
Naoko Mizuhara ,  Yoshinosuke Usuki ,  Masaki Ogita ,  Ken-Ichi Fujita ,  Manabu Kuroda ,  Matsumi Doe ,  Hideo Iio ,  Toshio Tanaka
PMID: 18277002 DOI: 10.1038/ja.2007.101
Abstract

In our survey for Antifungal compounds, a fermentation broth of Streptomyces sp. HA81-2 was found to inhibit the in vitro growth of Aspergillus fumigatus IFO 5840 accompanied by hyphal morphological abnormalities. One of the isolated Antibiotics was identified as phoslactomycin E based on LC-MS and NMR spectral data. In a preliminary assay using the membrane fractions of A. fumigatus, phoslactomycin E was found to inhibit the activity of 1,3-beta glucan synthase.

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