Synthesis of new benzimidazole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates with efficient DNA-binding affinity and potent cytotoxicity

  • Bioorg Med Chem Lett. 2008 Apr 15;18(8):2594-8. doi: 10.1016/j.bmcl.2008.03.039.
Ahmed Kamal  1 ,  P Praveen Kumar ,  K Sreekanth ,  B N Seshadri ,  P Ramulu
Affiliations
  • 1. Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India. [email protected]
PMID: 18378445 DOI: 10.1016/j.bmcl.2008.03.039
Abstract

The synthesis of new benzimidazole linked pyrrolobenzodiazepine conjugates is described. Some of these conjugates show significant DNA-binding affinity and, a representative compound 4c shows promising in vitro cytotoxicity against a number of human Cancer cell lines.