Central administration of Lys-D-Pro-Thr, an interleukin-1 beta 193-195 analogue, stimulates feeding in rats

  • Neuropeptides. 1991 May;19(1):9-11. doi: 10.1016/0143-4179(91)90067-s.
Y Uehara  1 ,  H Shimizu ,  Y Shimomura ,  M Negishi ,  A Fukatsu ,  K Kashima ,  Y Tanaka ,  I Kobayashi
Affiliations
  • 1. First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.
PMID: 1891074 DOI: 10.1016/0143-4179(91)90067-s
Abstract

We determined the effect on feeding of Lys-D-Pro-Thr (LDPT), an interleukin-1 beta 193-195 analogue which antagonizes the analgesic effects of interleukin-1 beta. Intracerebroventricular administration of 2 micrograms/rat LDPT increased food consumption at the 0-1 h time period, although food intake was reduced by LDPT at the 1-2 h time period. There was no effect on colonic temperature 1 h later. Subcutaneously injected LDPT (2 micrograms/rat) failed to increase food intake for 1 h. These data suggest that brain interleukin-1 beta may have a physiological role in feeding suppression.

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