Kuguacins F-S, cucurbitane triterpenoids from Momordica charantia

  • Phytochemistry. 2009 Jan;70(1):133-40. doi: 10.1016/j.phytochem.2008.10.011.
Jian-Chao Chen  1 ,  Wu-Qing Liu ,  Lu Lu ,  Ming-Hua Qiu ,  Yong-Tang Zheng ,  Liu-Meng Yang ,  Xian-Min Zhang ,  Lin Zhou ,  Zhong-Rong Li
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China.
PMID: 19041990 DOI: 10.1016/j.phytochem.2008.10.011
Abstract

Chemical investigation of the vines and leaves of Momordica charantia resulted in isolation of fourteen cucurbitane triterpenoids, kuguacins F-S (1-14), including two pentanorcucurbitacins (6 and 7), one octanorcucurbitacin (8), and two trinorcucurbitacins (11 and 12), along with six known analogues. Their structures were elucidated on the basis of extensive spectroscopic and single-crystal X-ray diffraction analyses. Compounds 1-14 exhibited weak anti-HIV-1 activities in vitro.

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