Discovery of novel small molecule cell type-specific enhancers of NF-kappaB nuclear translocation

  • Bioorg Med Chem Lett. 2009 Feb 15;19(4):1191-4. doi: 10.1016/j.bmcl.2008.12.086.
Gangli Gong  1 ,  Yuli Xie ,  Yidong Liu ,  Alison Rinderspacher ,  Shi-Xian Deng ,  Yan Feng ,  Zhengxiang Zhu ,  Yufei Tang ,  Michael Wyler ,  Nathalie Aulner ,  Udo Toebben ,  Deborah H Smith ,  Lars Branden ,  Caty Chung ,  Stephan Schürer ,  Dusica Vidović ,  Donald W Landry
Affiliations
  • 1. Department of Medicine, Columbia University, 650 W 168th Street, BB 1029, New York, NY 10032, USA.
PMID: 19136257 DOI: 10.1016/j.bmcl.2008.12.086
Abstract

An IKKbeta inhibitor reported to block NF-kappaB transcriptional activities in Jurkat T cells, was found to enhance NF-kappaB translocation in HUVEC cells. These studies suggested a noncanonical NF-kappaB signaling pathway independent of IKKbeta in HUVEC cells.