Ent-kaurane diterpenoids from Rabdosia rubescens and their cytotoxic effects on human cancer cell lines

  • Planta Med. 2010 Feb;76(2):140-5. doi: 10.1055/s-0029-1186002.
Naisheng Bai  1 ,  Kan He ,  Zhu Zhou ,  Mei-Ling Tsai ,  Li Zhang ,  Zheng Quan ,  Xi Shao ,  Min-Hsiung Pan ,  Chi-Tang Ho
Affiliations
  • 1. Department of Food Science, Rutgers University, New Brunswick, New Jersey 08901, USA.
PMID: 19653147 DOI: 10.1055/s-0029-1186002
Abstract

Two new ent-kaurane Diterpenoids, 16,17-exo-epoxide-oridonin ( 1) and 11,15- O,O-diacetyl-rabdoternins D ( 2), together with thirteen known ones, were isolated from the aerial parts of Rabdosia rubescens. Their structures were established on the basis of high-field 1D and 2D NMR methods supported by HRMS. All Diterpenoids were tested for cytotoxicity against human Hep G2, COLO 205, MCF-7, and HL-60 Cancer cells. The compounds oridonin ( 3), 14- O-acetyl-oridonin ( 4), 1,14- O,O-diacetyl-oridonin ( 5), rosthorin ( 6), effusanin E ( 7), and ponicidin ( 8), as well as six alpha-methylene gamma-ketone bearing Diterpenoids, were modestly active in these assays.

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