Gamma-lactones and ent-eudesmane sesquiterpenes from the endophytic fungus Eutypella sp. BCC 13199

  • J Nat Prod. 2009 Sep;72(9):1720-2. doi: 10.1021/np900316x.
Masahiko Isaka  1 ,  Somporn Palasarn ,  Sanisa Lapanun ,  Rungtiwa Chanthaket ,  Nattawut Boonyuen ,  Saisamorn Lumyong
Affiliations
  • 1. National Center for Genetic Engineering and Biotechnology, 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand.
PMID: 19739600 DOI: 10.1021/np900316x
Abstract

Two new gamma-lactones, eutypellins A (1) and B (2), and two ent-eudesmane Sesquiterpenes, ent-4(15)-eudesmen-11-ol-1-one (3) and ent-4(15)-eudesmen-1alpha,11-diol (4), together with three known pimarane diterpenes, diaporthein B, scopararane A, and libertellenone C, were isolated from the endophytic fungus Eutypella sp. BCC 13199. The structures of these compounds were elucidated by interpretation of spectroscopic data. The absolute configuration of 4 was confirmed by application of the modified Mosher's method. Eutypellin A (1) and sesquiterpene 3 exhibited weak cytotoxic activities.