Carnitine conjugate of nipecotic acid: a new example of dual prodrug

  • Molecules. 2009 Aug 31;14(9):3268-74. doi: 10.3390/molecules14093268.
Carmela Napolitano  1 ,  Martina Scaglianti ,  Emanuela Scalambra ,  Stefano Manfredini ,  Luca Ferraro ,  Sarah Beggiato ,  Silvia Vertuani
Affiliations
  • 1. Department of Pharmaceutical Sciences, University of Ferrara, Via Fossato di Mortara 17-19, I-44100 Ferrara, Italy.
PMID: 19783924 DOI: 10.3390/molecules14093268
Abstract

As a novel example of improved entry of poorly delivered drugs into the brain by means of nutrient conjugates, L-carnitine was conjugated to nipecotic acid and the capacity to antagonize PTZ-induced convulsions of this novel entity was evaluated.

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