Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands

  • Bioorg Med Chem Lett. 2009 Dec 1;19(23):6806-9. doi: 10.1016/j.bmcl.2009.09.033.
Enrico Morera  1 ,  Luciano De Petrocellis ,  Ludovica Morera ,  Aniello Schiano Moriello ,  Alessia Ligresti ,  Marianna Nalli ,  David F Woodward ,  Vincenzo Di Marzo ,  Giorgio Ortar
Affiliations
  • 1. Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, 00185 Roma, Italy.
PMID: 19875281 DOI: 10.1016/j.bmcl.2009.09.033
Abstract

The evaluation of a series of piperazinyl carbamates and ureas, designed on the basis of previously reported TRPV1 antagonists and FAAH inhibitors, led to the identification of some 'dual-action' compounds targeting both FAAH and TRPV1 or TRPA1 receptors.