Verticilide, a new ryanodine-binding inhibitor, produced by Verticillium sp. FKI-1033

  • J Antibiot (Tokyo). 2010 Feb;63(2):77-82. doi: 10.1038/ja.2009.126.
Kazuro Shiomi  1 ,  Ryosuke Matsui ,  Atsuo Kakei ,  Yuichi Yamaguchi ,  Rokuro Masuma ,  Hiroko Hatano ,  Noriko Arai ,  Miki Isozaki ,  Haruo Tanaka ,  Susumu Kobayashi ,  Andreas Turberg ,  Satoshi Omura
Affiliations
  • 1. Kitasato Institute for Life Sciences, Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan. [email protected]
PMID: 20057513 DOI: 10.1038/ja.2009.126
Abstract

A new ryanodine-binding inhibitor, verticilide, was isolated from the cultured broth of a fungus, Verticillium sp. FKI-1033. It is a 24-membered ring cyclic depsipeptide, its structure being elucidated as cyclo[(2R)-2-hydroxyheptanoyl-N-methyl- L-alanyl](4). Verticilide inhibited ryanodine binding to ryanodine receptors in the cockroach at an IC(50) value of 4.2 microM, whereas inhibition against mouse ryanodine receptors was weak (IC(50)=53.9 microM).

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