Amino acids and peptides. XXX. Synthesis of eglin c (41-49) and eglin c (60-63) and examination of their inhibitory activity towards human leukocyte elastase, cathepsin G, porcine pancreatic elastase and alpha-chymotrypsin

  • Chem Pharm Bull (Tokyo). 1991 Jan;39(1):184-6. doi: 10.1248/cpb.39.184.
S Tsuboi  1 ,  M Takeda ,  Y Okada ,  Y Nagamatsu ,  J Yamamoto
Affiliations
  • 1. Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan.
PMID: 2049802 DOI: 10.1248/cpb.39.184
Abstract

H-Ser-Pro-Val-Thr-Leu-Asp-Leu-Arg-Tyr-OH and H-Thr-Asn-Val-Val-OH, which correspond to the sequences 41-49 and 60-63 of eglin c, respectively, were synthesized by a conventional solution approach using the newly developed 6-chloro-2-pyridyl ester method. The inhibitory activities of the above two peptides against human leukocyte Elastase, Cathepsin G, porcine pancreatic Elastase and alpha-chymotrypsin were examined in comparison with those of the corresponding methyl esters.

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