Antiproliferative diterpenoids from the leaves of Isodon rubescens

  • Planta Med. 2011 Jan;77(2):169-74. doi: 10.1055/s-0030-1250165.
Xue-Mei Gao  1 ,  Xiao Luo ,  Jian-Xin Pu ,  Ying-Li Wu ,  Yong Zhao ,  Li Bin Yang ,  Fei He ,  Xiao Nian Li ,  Wei-Lie Xiao ,  Guo-Qiang Chen ,  Han-Dong Sun
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, People's Republic of China.
PMID: 20669088 DOI: 10.1055/s-0030-1250165
Abstract

A phytochemical study of Isodon rubescens leaves led to the isolation of five new Diterpenoids, isorubesins A-E ( 1- 5), and fifteen known Diterpenoids. The structures of these new compounds were elucidated by spectroscopic evidence. Most of the Diterpenoids were tested for cytotoxicity against NB4, A549, SHSY5Y, PC3, and MCF7 human tumor cells. Some of them showed potent inhibitory activity. Compound 5 is the first reported atisane-type diterpenoid from this plant.

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