28-nor-oleanane-type triterpene saponins from Camellia japonica and their inhibitory activity on LPS-induced NO production in macrophage RAW264.7 cells

  • Bioorg Med Chem Lett. 2010 Dec 15;20(24):7435-9. doi: 10.1016/j.bmcl.2010.10.013.
Nguyen Thi Phuong Thao  1 ,  Tran Manh Hung ,  To Dao Cuong ,  Jin Cheol Kim ,  Eun Hee Kim ,  Seong Eun Jin ,  MinKyun Na ,  Young Mi Lee ,  Young Ho Kim ,  Jae Sue Choi ,  Byung Sun Min
Affiliations
  • 1. College of Pharmacy, Catholic University of Daegu, Gyeongsan, Republic of Korea.
PMID: 21050759 DOI: 10.1016/j.bmcl.2010.10.013
Abstract

Four new 28-nor-oleanane-type triterpene oligoglycosides, camellenodiol 3-O-β-D-galactopyranosyl(1→2)[β-D-xylopyranosyl(1→2)-β-D-galactopyranosyl(1→3)]-β-D-glucuronopyranoside (2), camellenodiol 3-O-4''-O-acetyl-β-D-galactopyranosyl(1→2)[β-D-xylopyranosyl(1→2)-β-D-galactopyranosyl(1→3)]-β-D-glucuronopyranoside (4), camellenodiol 3-O-(β-D-galactopyranosyl(1→2)[β-D-xylopyranosyl(1→2)-β-D-galactopyranosyl(1→3)]-6'-methoxy-β-D- glucuronopyranoside (5), and maragenin II 3-O-(β-D-galactopyranosyl(1→2)[β-D-xylopyranosyl(1→2)-β-D-galactopyranosyl(1→3)]-6'-methoxy-β-D-glucuronopyranoside (6), along with two known compounds, (1 and 3), were isolated from the stem bark of Camellia japonica. Their chemical structures were established mainly by 2D NMR techniques and mass spectrometry. The isolated compounds showed inhibitory effects on NO production in RAW264.7 macrophages.