Cytotoxic quassinoids from Ailanthus altissima

  • Bioorg Med Chem Lett. 2013 Feb 1;23(3):654-7. doi: 10.1016/j.bmcl.2012.11.116.
Yan Wang  1 ,  Wen-Jing Wang ,  Chang Su ,  Dong-Mei Zhang ,  Li-Peng Xu ,  Rong-Rong He ,  Lei Wang ,  Jian Zhang ,  Xiao-Qi Zhang ,  Wen-Cai Ye
Affiliations
  • 1. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, PR China.
PMID: 23290052 DOI: 10.1016/j.bmcl.2012.11.116
Abstract

Two new quassinoids, altissinol A (1) and B (7), together with 12 known quassinoids, were isolated from the 95% ethanol extract of the barks of Ailanthus altissima. The structures of the new compounds (1 and 7) were determined on the basis of the spectroscopic methods including UV, IR, HR-ESI-MS, 1D and 2D NMR. The cytotoxic potential of all isolates were evaluated in vitro against three human hepatoma cell lines. Quassinoids 1-7 displayed potent cytotoxic activities against human hepatoma Hep3B and HepG2 cell lines. Interestingly, compounds 2, 3, and 5 exhibited cytotoxic activity against multidrug resistance HepG2/ADM cell line with IC(50) value 4.3-fold more sensitive to Doxorubicin (DOX).

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