Constituents of the aerial parts of Eclipta prostrata and their cytotoxicity on human ovarian cancer cells in vitro

  • Arch Pharm Res. 2015 Nov;38(11):1963-9. doi: 10.1007/s12272-015-0599-2.
Ha-Yeong Kim  1 ,  Hye Mi Kim  2 ,  Byeol Ryu  1 ,  Jae-Seung Lee  1 ,  Jung-Hye Choi  1  2 ,  Dae Sik Jang  3  4
Affiliations
  • 1. Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, 130-701, Republic of Korea.
  • 2. College of Pharmacy, Kyung Hee University, Seoul, 130-701, Republic of Korea.
  • 3. Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, 130-701, Republic of Korea. [email protected].
  • 4. College of Pharmacy, Kyung Hee University, Seoul, 130-701, Republic of Korea. [email protected].
PMID: 25855013 DOI: 10.1007/s12272-015-0599-2
Abstract

A new terthiophene, 3'-hydroxy-2,2':5',2″-terthiophene-3'-O-β-D-glucopyranoside (1) and a new oleanane-type saponin, echinocystic acid-3-O-(6-O-acetyl)-β-D-glucopyranoside (7) were isolated from the aerial parts of Eclipta prostrata L. Moreover, five thiophenes (2-6), seven triterpenoids (8-14), two coumestans (15 and 16), and four Flavonoids (17-20) having previously known chemical structures were isolated during the same course of this study. All the isolates 1-20 were evaluated for their cytotoxicity against human ovarian Cancer cells (SKOV3) using MTT assays.

Keywords
Cytotoxicity; Eclipta prostrata; Ovarian cancer; Terthiophene; Triterpenoid.
Products