The effect of RO3201195 and a pyrazolyl ketone P38 MAPK inhibitor library on the proliferation of Werner syndrome cells
- Org Biomol Chem. 2016 Jan 21;14(3):947-56. doi: 10.1039/c5ob02229k.
Affiliations
- 1. Department of Chemistry, School of Life Sciences, University of Sussex, Falmer, Brighton, East Sussex, BN1 9QJ, UK. [email protected].
PMID: 26611938
DOI: 10.1039/c5ob02229k
Abstract
Microwave-assisted synthesis of the pyrazolyl ketone p38 MAPK Inhibitor RO3201195 in 7 steps and 15% overall yield, and the comparison of its effect upon the proliferation of Werner Syndrome cells with a library of pyrazolyl ketones, strengthens the evidence that p38 MAPK inhibition plays a critical role in modulating premature cellular senescence in this progeroid syndrome and the reversal of accelerated ageing observed in vitro on treatment with SB203580.