A self-assembling β-peptide hydrogel for neural tissue engineering

  • Soft Matter. 2016 Feb 28;12(8):2243-6. doi: 10.1039/c5sm02902c.
S Motamed  1 ,  M P Del Borgo  2 ,  K Kulkarni  3 ,  N Habila  2 ,  K Zhou  1 ,  P Perlmutter  3 ,  J S Forsythe  1 ,  M I Aguilar  2
Affiliations
  • 1. Department of Materials Science and Engineering, Monash Institute of Medical Engineering, Monash University, Clayton, Vic 3800, Australia. [email protected].
  • 2. Monash Biomedicine Discovery Institute and Department of Biochemistry & Molecular Biology, Monash University, Clayton, Vic 3800, Australia. [email protected].
  • 3. School of Chemistry, Monash University, Clayton, Vic 3800, Australia.
PMID: 26853859 DOI: 10.1039/c5sm02902c
Abstract

We report a new class of β-peptide based hydrogel for neural tissue engineering. Our β-peptide forms a network of nanofibres in aqueous solution, resulting in a stable hydrogel at physiological conditions. The hydrogel shows excellent compatibility with neural cells and provides a suitable environment for cells to adhere and proliferate.

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