Polycycloiridals with a Cyclopentane Ring from Iris tectorum

  • J Nat Prod. 2017 Jan 27;80(1):156-161. doi: 10.1021/acs.jnatprod.6b00796.
Chun-Lei Zhang  1  2 ,  Zhi-You Hao  1 ,  Yan-Fei Liu  1 ,  Yan Wang  1 ,  Guo-Ru Shi  1 ,  Zhi-Bo Jiang  1 ,  Ruo-Yun Chen  1 ,  Zheng-Yu Cao  2 ,  De-Quan Yu  1
Affiliations
  • 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
  • 2. Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of TCM, China Pharmaceutical University , Nanjing 211198, People's Republic of China.
PMID: 28032759 DOI: 10.1021/acs.jnatprod.6b00796
Abstract

Six new iridal-type triterpenoids containing an unprecedented cyclopentane ring, polycycloiridals E-J (1-6), were isolated from a large-scale re-extraction of Iris tectorum. A possible biosynthesis pathway is postulated. The known spirioiridotectal D (7) was also obtained in the current investigation, and its structure was unequivocally defined using X-ray diffraction data. Compound 7 suppressed LPS-activated NO production in the BV2 cell line with an IC50 value of 0.54 μM.