An antimicrobial peptide with an aggregation-induced emission (AIE) luminogen for studying bacterial membrane interactions and antibacterial actions

  • Chem Commun (Camb). 2017 Mar 16;53(23):3315-3318. doi: 10.1039/c6cc09408b.
Ning Ning Li  1 ,  Jun Zhi Li  1 ,  Peng Liu  2 ,  Dicky Pranantyo  2 ,  Lei Luo  3 ,  Jiu Cun Chen  1 ,  En-Tang Kang  2 ,  Xue Feng Hu  4 ,  Chang Ming Li  1 ,  Li Qun Xu  1
Affiliations
  • 1. Institute for Clean Energy and Advanced Materials, Faculty of Materials and Energy, Southwest University, Chongqing, 400715, China. [email protected] [email protected].
  • 2. Department of Chemical & Biomolecular Engineering, National University of Singapore, 117576, Singapore.
  • 3. College of Pharmaceutical Science, Southwest University, Chongqing, 400715, China.
  • 4. National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, China. [email protected].
PMID: 28078346 DOI: 10.1039/c6cc09408b
Abstract

A fluorescence technique to investigate the interactions between Bacterial membranes and an aggregation-induced emission (AIE) luminogen-decorated AMP (TPE-AMP) was reported. Our simple and fast method consists of mixing TPE-AMP and Bacterial suspensions and recording the fluorescence signals by flow cytometry and confocal microscopy in a "non-washing" manner.

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