Kitamycin C, a new antimycin-type antibiotic from Streptomyces antibioticus strain 200-09

  • Nat Prod Res. 2017 Aug;31(15):1819-1824. doi: 10.1080/14786419.2017.1295240.
Fan Wang  1 ,  Shu-Na Fu  1 ,  Yi-Xuan Bao  1 ,  Yu Yang  1 ,  Hui-Fang Shen  2 ,  Bi-Run Lin  2 ,  Guang-Xiong Zhou  1
Affiliations
  • 1. a Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research , Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University , Guangzhou , China.
  • 2. b Key Laboratory of New Technique for Plant Protection in Guangdong , Institute of Plant Protection, Guangdong Academy of Agricultural Sciences , Guangzhou , China.
PMID: 28278640 DOI: 10.1080/14786419.2017.1295240
Abstract

An actinomycete strain 200-09, isolated from a soil sample collected from the coast of Hawaii, USA, was identified as Streptomyces antibioticus on the basis of its morphological, physiological and biochemical characteristics as well as 16S rDNA analysis. A new antimycin-type Antibiotic, kitamycin C (1), together with kitamycin A (2), kitamycin B (3), urauchmycin B (4), deisovaleryblastomycin (5) was isolated from a cultured broth of strain 200-09. The structure of the new compound was determined by spectroscopic data, including HR-ESI-MS and NMR. All the compounds exhibited Antifungal activities against Candida albicans with MIC of about 25.0 μg mL-1.

Keywords
Streptomyces antibioticus; antifungal activity; antimycin; kitamycin C.
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