Flavanonol glucosides from the aerial parts of Agrimonia pilosa Ledeb. and their acetylcholinesterase inhibitory effects

  • Carbohydr Res. 2017 Jun 5:445:75-79. doi: 10.1016/j.carres.2017.04.014.
U Min Seo  1 ,  Duc Hung Nguyen  2 ,  Bing Tian Zhao  1 ,  Byung Sun Min  1 ,  Mi Hee Woo  3
Affiliations
  • 1. College of Pharmacy, Catholic University of Daegu, Gyeongsan 38430, Republic of Korea.
  • 2. College of Pharmacy, Catholic University of Daegu, Gyeongsan 38430, Republic of Korea; Phutho College of Pharmacy, Viettri City, Phutho Province 290000, Viet Nam.
  • 3. College of Pharmacy, Catholic University of Daegu, Gyeongsan 38430, Republic of Korea. Electronic address: [email protected].
PMID: 28458099 DOI: 10.1016/j.carres.2017.04.014
Abstract

Two new flavanonol glucoside isomers, (2R,3S)-dihydrokaempferol 3-O-β-D-glucoside (1) and (2S,3R)-dihydrokaempferol 3-O-β-D-glucoside (2), were isolated from the aerial parts of Agrimonia pilosa Ledeb., along with eight known flavanonol glucosides (3-10). Their structures were determined on the basis of spectroscopic analysis. In addition, these compounds were evaluated to determine their acetylcholinesterase inhibitory activities. The results indicated that these compounds have moderate inhibitory effects, with IC50 values ranging from 76.59 ± 1.16 to 97.53 ± 1.64 μM, except compounds 1 and 4 were inactive.

Keywords
Acetylcholinesterase activity; Agrimonia pilosa; Flavanonol glucoside.
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