Leucomyosuppressin, a novel insect neuropeptide, inhibits evoked transmitter release at the mealworm neuromuscular junction

  • Neurosci Lett. 1988 Dec 19;95(1-3):137-42. doi: 10.1016/0304-3940(88)90646-5.
D Yamamoto  1 ,  S Ishikawa ,  G M Holman ,  R J Nachman
Affiliations
  • 1. Laboratory of Neurophysiology, Mitsubishi-Kasei Institute of Life Sciences, Tokyo, Japan.
PMID: 2852317 DOI: 10.1016/0304-3940(88)90646-5
Abstract

The action of leucomyosuppressin (LMS: pGlu-Asp-Val-Asp-His-Val-Phe-Leu-Arg-Phe-NH2) on the glutamate-mediated neuromuscular transmission in the mealworm, Tenebrio molitor, was studied by the microelectrode current-clamp and voltage-clamp techniques. Submicromolar concentrations of LMS reversibly attenuate evoked release of transmitter from the motor nerve terminals, as evidenced by a decrease in the quantum content estimated by the number of failures of extracellular EPSPs. LMS has no effect on the glutamate-induced depolarization. Possible intracellular mediators for the LMS action are discussed.

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