A new fatty acid ester from Nigella sativa var. hispidula Boiss showing potent anti-protein tyrosine phosphatase 1B activity

  • Nat Prod Res. 2019 Feb;33(4):472-476. doi: 10.1080/14786419.2017.1396594.
Xixi Liu  1  2 ,  Haji Akber Aisa  1 ,  Xuelei Xin  1
Affiliations
  • 1. a Key Laboratory of Plant Resources and Chemistry of Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization , Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi , PR China.
  • 2. b University of Chinese Academy of Sciences , Beijing , PR China.
PMID: 29086598 DOI: 10.1080/14786419.2017.1396594
Abstract

A new fatty acid ester (1) and seven known phenolic compounds, i.e. salfredin B11 (2), nigephenol C (3), nigephenol B (4), acetovanillion (5), p-hydroxybenzoic acid (6), p-hydroxy-acetophenone (7) and p-hydroxybenzaldehyde (8), were isolated from the seeds of Nigella sativa var. hispidula. Among them, compounds 5, 7 and 8 were isolated from Nigella for the first time. Their structures were elucidated with HR-ESI-MS, 1D and 2D NMR spectra. Evaluation of the isolated compounds on protein tyrosine Phosphatase (PTP1B) assay indicated that although compounds 2-8 show no promising anti-PTP1B activities, compound 1 possess anti-PTP1B activity with an IC50 value of 7.38 ± 0.14 μM in vitro.

Keywords
var.; anti-PTP1B activity; fatty acid ester; phenolic compounds.
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