Three new cyathane diterpenes with neurotrophic activity from the liquid cultures of Hericium erinaceus

  • J Antibiot (Tokyo). 2018 Sep;71(9):818-821. doi: 10.1038/s41429-018-0065-8.
Yuting Zhang  1  2 ,  Li Liu  1  2 ,  Li Bao  3 ,  Yanlong Yang  1 ,  Ke Ma  1  2 ,  Hongwei Liu  4  5
Affiliations
  • 1. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, No. 1 Beichenxi Road, Chaoyang District, Beijing, 100101, People's Republic of China.
  • 2. Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
  • 3. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, No. 1 Beichenxi Road, Chaoyang District, Beijing, 100101, People's Republic of China. [email protected].
  • 4. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, No. 1 Beichenxi Road, Chaoyang District, Beijing, 100101, People's Republic of China. [email protected].
  • 5. Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China. [email protected].
PMID: 29780164 DOI: 10.1038/s41429-018-0065-8
Abstract

Three new cyathane diterpenes erinacines T-V (1-3), and two known cyathane diterpenes erinacine A (4) and erinacine P (5) were isolated from the liquid cultures of Hericium erinaceus. The structures of 1-3 were determined by extensive spectroscopic analysis. All isolated compounds were evaluated for the cytotoxicity, and neurite-promoting activities using PC12 cell line. Compounds 1-3, and 5 exhibited pronounced neurite outgrowth-promoting effects on PC12 cells in the range of 2.5-10 μM. Compound 4 showed weak cytotoxicity against PC12 cells with IC50 of 73.7 μM.

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