Aplasmomycin and boromycin are specific inhibitors of the futalosine pathway

  • J Antibiot (Tokyo). 2018 Nov;71(11):968-970. doi: 10.1038/s41429-018-0087-2.
Yohei Shimizu  1 ,  Yasushi Ogasawara  2 ,  Atsuko Matsumoto  3 ,  Tohru Dairi  4
Affiliations
  • 1. Graduate School of Engineering, Hokkaido University, Sapporo, Hokkaido, 060-8628, Japan.
  • 2. Graduate School of Engineering, Hokkaido University, Sapporo, Hokkaido, 060-8628, Japan. [email protected].
  • 3. Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, 108-8641, Japan.
  • 4. Graduate School of Engineering, Hokkaido University, Sapporo, Hokkaido, 060-8628, Japan. [email protected].
PMID: 30089869 DOI: 10.1038/s41429-018-0087-2
Abstract

We searched for specific inhibitors of the futalosine pathway, non-canonical pathway of menaquinone biosynthesis operating in Helicobacter pylori, from metabolites produced by actinomycetes. Aplasmomycin, a boron-containing macrodiolide, was isolated from Streptomyces sp. K15-0223 as a specific inhibitor of the futalosine pathway. We also showed boromycin, an analog of aplasmomycin, had similar activity.

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