CDy14: a novel biofilm probe targeting exopolysaccharide Psl

  • Chem Commun (Camb). 2018 Oct 18;54(84):11865-11868. doi: 10.1039/c8cc05544k.
Haw-Young Kwon  1 ,  Jun-Young Kim ,  Jung Yeol Lee ,  Joey Kuok Hoong Yam ,  Louise Dahl Hultqvist ,  Wang Xu ,  Morten Rybtke ,  Tim Tolker-Nielsen ,  Jong-Jin Kim ,  Nam-Young Kang ,  Liang Yang ,  Sung-Jin Park ,  Michael Givskov ,  Young-Tae Chang
Affiliations
  • 1. Center for Self-assembly and Complexity, Institute for Basic Science (IBS), Pohang 37673, Republic of Korea.
PMID: 30204158 DOI: 10.1039/c8cc05544k
Abstract

Detection of biofilm bacteria would be an ideal method for the physicians to diagnose chronic Bacterial infections directly, but there are few imaging probes available so far. Here, we report the development of a novel biofilm detecting fluorescent probe, CDy14, through an unbiased screening of a fluorescence library and elucidated its binding partner Psl, an exopolysaccharide of the biofilm.

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