l,8-Naphthalimide based DNA intercalators and anticancer agents. A systematic review from 2007 to 2017
- Eur J Med Chem. 2018 Nov 5:159:393-422. doi: 10.1016/j.ejmech.2018.09.055.
- 1. Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Silesian University of Technology, B. Krzywoustego 4, 44-100, Gliwice, Poland.
- 2. Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Silesian University of Technology, B. Krzywoustego 4, 44-100, Gliwice, Poland. Electronic address: [email protected].
In this review, we describe a detailed investigation about the structural variations and relative activity of 1,8-naphthalimide based intercalators and Anticancer agents. The 1,8-naphthalimides binds to the DNA via intercalation, and exert their antitumor activities through Topoisomerase I/II inhibition, photoinduced DNA damage or related mechanism. Here, our discussion focused on works published over the last ten years (2007-2017) related to therapeutic applications, in the order of Cancer treatment followed by Other properties of 1,8-naphthalimides. In preparing for this review, we considered that several seminal reviews have appeared over the last fifteen years and focused on closely related subjects, however, none of them is exhaustive.