Sesquiterpenoids from the Endophytic Fungus Rhinocladiella similis

  • J Nat Prod. 2019 May 24;82(5):1055-1062. doi: 10.1021/acs.jnatprod.8b00938.
Shuai Liu  1  2 ,  Yuping Zhao  2 ,  Christian Heering  3 ,  Christoph Janiak  3 ,  Werner E G Müller  4 ,  Sergi Hervé Akoné  1  5 ,  Zhen Liu  1 ,  Peter Proksch  1
Affiliations
  • 1. Institute of Pharmaceutical Biology and Biotechnology , Heinrich-Heine-Universität Düsseldorf , 40225 Düsseldorf , Germany.
  • 2. Faculty of Life Science and Food Engineering , Huaiyin Institute of Technology , Huaian 223003 , People's Republic of China.
  • 3. Institute of Inorganic and Structural Chemistry , Heinrich-Heine-Universität Düsseldorf , 40225 Düsseldorf , Germany.
  • 4. Institute of Physiological Chemistry , Universitätsmedizin der Johannes Gutenberg-Universität Mainz , 55128 Mainz , Germany.
  • 5. Department of Chemistry, Faculty of Science , University of Douala , PO Box 24157, Douala , Cameroon.
PMID: 31044595 DOI: 10.1021/acs.jnatprod.8b00938
Abstract

Ten new sesquiterpenoid derivatives, rhinomilisins A-J (1-10), along with six known analogues (11-16), were isolated from the mangrove-derived endophytic fungus Rhinocladiella similis. The structures of the new compounds were elucidated by their NMR and MS data, while the absolute configuration of 3 and 6 was determined by X-ray crystallographic analysis and Mosher's method, respectively. All isolated compounds (1-16) were evaluated for their cytotoxicity against the mouse lymphoma cell line L5178Y, and compounds 1, 7, and 15 showed moderate activity with IC50 values of 5.0, 8.7, and 24.4 μM, respectively.