Renoprotective ganodermaones A and B with rearranged meroterpenoid carbon skelotons from Ganoderma fungi

  • Bioorg Chem. 2020 Jul;100:103930. doi: 10.1016/j.bioorg.2020.103930.
Jiao-Jiao Zhang  1 ,  Fu-Ying Qin  1 ,  Xiao-Hui Meng  1 ,  Yong-Ming Yan  1 ,  Yong-Xian Cheng  2
Affiliations
  • 1. School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, People's Republic of China.
  • 2. School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, People's Republic of China. Electronic address: [email protected].
PMID: 32450386 DOI: 10.1016/j.bioorg.2020.103930
Abstract

Two structurally novel meroterpenoids, ganodermaones A (1) and B (2), were isolated from Ganoderma fungi (G. cochlear and G. lucidum). The structures of 1 and 2 were assigned by spectroscopic, computational, and X-ray diffraction methods. Compounds 1 and 2 represent the first examples of meroterpenoids in Ganoderma Fungal species featuring with carbon migration. The plausible biosynthetic pathway for 1 was proposed. Biological evaluation showed that both 1 and 2 could inhibit renal fibrosis in TGF-β1-induced kidney proximal tubular cells.

Keywords
Carbon migration; Ganoderma cochlear; Ganoderma lucidum; Meroterpenoids; Renal fibrosis.
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