Analogs of the carotane antibiotic fulvoferruginin from submerged cultures of a Thai Marasmius sp

  • Beilstein J Org Chem. 2021 Jun 4:17:1385-1391. doi: 10.3762/bjoc.17.97.
Birthe Sandargo  1 ,  Leon Kaysan  1  2 ,  Rémy B Teponno  1  3 ,  Christian Richter  1 ,  Benjarong Thongbai  1 ,  Frank Surup  1 ,  Marc Stadler  1  4
Affiliations
  • 1. Microbial Drugs Department, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
  • 2. Technical University of Ilmenau, 98693 Ilmenau, Germany.
  • 3. Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
  • 4. Institute of Microbiology, Technical University of Braunschweig, Germany.
PMID: 34136017 DOI: 10.3762/bjoc.17.97
Abstract

A recent find of a Marasmius species in Northern Thailand led to the isolation of five unprecedented derivatives of the carotane Antibiotic fulvoferruginin (1), fulvoferruginins B-F (2-6). The structures of these sesquiterpenoids were elucidated using HRESIMS, 1D and 2D NMR, as well as CD spectroscopy. Assessing the bioactivity, fulvoferruginin emerged as a potent cytotoxic agent of potential pharmaceutical interest.

Keywords
Basidiomycota; Marasmius; antibiotics; carotane; fulvoferruginin; sesquiterpenoid.
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